Alternative treatment of diabetic foot: results of topical honey use in elderly patients

Authors

DOI:

https://doi.org/10.63688/ihs.v1.i1.3

Keywords:

diabetic foot, honey, wound healing, diabetes mellitus.

Abstract

Diabetic foot is one of the most severe complications of diabetes mellitus and remains a leading cause of non-traumatic amputations worldwide. This condition significantly affects patients' quality of life, places a heavy burden on healthcare systems, and compromises the functional autonomy of those affected. In this context, the present study aimed to evaluate the effectiveness of topical honey application in the healing process of ulcers in insulin-dependent elderly patients diagnosed with diabetic foot. The study employed an observational and experimental approach, involving a sample of 20 individuals treated between September 2022 and June 2023. Regular wound dressings using honey were applied in both clinical and home settings, and variables such as wound evolution, overall patient condition, and blood glucose stability were analyzed. Results showed significant improvement in 85% of cases, including reduced exudate, tissue regeneration, and progressive epithelialization, without adverse effects or metabolic alterations. Honey proved to be a safe, cost-effective, and efficient therapeutic alternative, capable of being integrated into conventional treatment plans in settings with limited access to advanced medical technologies. These findings highlight the importance of promoting further research and the development of clinical protocols that include natural products as a valid option in the comprehensive management of diabetic foot.

References

Cañarte Acivar MD, Intriago Ganchozo AS, Romero Santillán MA. Caracterización clínica y epidemiológica del pie diabético en pacientes del Hospital IESS Portoviejo. Rev Cient Dominio Cienc. 2016;2(4):259-276. https://doi.org/10.23857/dc.v2i4.277

Armstrong DG, Boulton AJM, Bus SA. Diabetic foot ulcers and their recurrence. N Engl J Med. 2017;376(24):2367-2375. https://doi.org/10.1056/NEJMra1615439

International Diabetes Federation. IDF Diabetes Atlas. 10th ed. Brussels: International Diabetes Federation; 2021. https://diabetesatlas.org/atlas/tenth-edition/

World Health Organization. Global report on diabetes [Internet]. 2023 [citado 18 sep 2026]. https://www.who.int/publications/i/item/9789241565257

Molassiotis A, Morris P, Bai Y. The effectiveness of honey in promoting wound healing: a systematic review. Int J Nurs Stud. 2021;123:104058. https://doi.org/10.1016/j.ijnurstu.2021.104058

Jull AB, Cullum N, Dumville JC, Westby MJ, Deshpande S, Walker N. Honey as a topical treatment for wounds. Cochrane Database Syst Rev. 2015;(3):CD005083. https://doi.org/10.1002/14651858.CD005083.pub4

Guadalupe JD. Uso de la miel tópica en el tratamiento de pacientes con úlceras de pie diabético [Internet]. Rev Enferm Vasc. 2023 Mar 16 [citado 18 sep 2026]. https://www.revistaevascular.es/index.php/revistaenfermeriavascular/article/view/133/162

Boulton AJM. The diabetic foot. Medicine. 2018;46(3):181-186. https://doi.org/10.1016/j.mpmed.2017.12.008

Edmonds M, Foster A. Managing the diabetic foot. BMJ. 2021;372:n72. https://doi.org/10.1136/bmj.n72

Bus SA, Lavery LA, Monteiro-Soares M, Rasmussen A, Raspovic A, Sacco ICN, et al. Guidelines on the prevention of foot ulcers in persons with diabetes (IWGDF 2019 update). Diabetes Metab Res Rev. 2020;36(S1):e3269. https://doi.org/10.1002/dmrr.3269

World Health Organization. Clasificación Internacional de Enfermedades (CIE-10) [Internet]. 2022 [citado 18 sep 2026]. https://www.who.int/classifications/icd/en/

Jeffcoate WJ, Harding KG. Diabetic foot ulcers. Lancet. 2003;361(9368):1545-1551. https://doi.org/10.1016/S0140-6736(03)13169-8

Organización Panamericana de la Salud. Tendencia de la tasa estandarizada de años vividos con discapacidad (AVD) debido a la diabetes, por sexo, 2000-2019 [Internet]. 2019 [citado 18 sep 2026]. https://iris.paho.org/handle/10665.2/51681

Ministerio de Salud Pública del Ecuador. Informe mensual de atenciones podológicas en el Hospital Isidro Ayora, Loja [Internet]. 2023 [citado 18 sep 2026]. https://www.salud.gob.ec

Ministerio de Salud Pública del Ecuador. MSP implementa unidades de atención integral para el pie diabético en 10 hospitales [Internet]. 2023 [citado 18 sep 2026]. https://www.salud.gob.ec/msp-implementa-unidades-de-atencion-integral-para-el-pie-diabetico-en-10-hospitales/

Molan PC. Potential of honey in the treatment of wounds and burns. Am J Clin Dermatol. 2001;2(1):13-19. https://doi.org/10.2165/00128071-200102010-00003

Al-Waili N, Salom K, Al-Ghamdi AA, Ansari MJ. Honey and microbial infections: a review supporting the use of honey for microbial control. J Med Food. 2011;14(10):1079-1096. https://doi.org/10.1089/jmf.2010.0161

Zhang Y, Liu M, Luo G, et al. The antibacterial and wound healing properties of honey. Evid Based Complement Alternat Med. 2019;2019:1-10. https://doi.org/10.1155/2019/7285612

Mensah AY, Sampson J, Houghton PJ, Hylands PJ, Westbrook J, Dunn M, et al. Effects of honey on wound healing. J Ethnopharmacol. 2001;75(2-3):103-107. https://doi.org/10.1016/S0378-8741(00)00382-3

Liu M, Luo G, Wang Y, Xu R, Wang Y, He W, et al. Nano-silver dressing combined with honey for wound healing. J Nanomater. 2018;2018:1-10. https://doi.org/10.1155/2018/2018065

Ousey K, Cutting KF, Rogers AA, Rippon MG. The importance of hydration in wound healing. J Wound Care. 2016;25(3):122-130. https://doi.org/10.12968/jowc.2016.25.3.122

Game FL, Apelqvist J, Attinger C, et al. Effectiveness of interventions to enhance healing of chronic ulcers of the foot in diabetes. Diabetes Metab Res Rev. 2020;36(S1):e3284. https://doi.org/10.1002/dmrr.3284

Kamaratos AV, Tzirogiannis KN, Iraklianou SA, Panoutsopoulos GI, Kanellos IE, Melidonis AI. Manuka honey-impregnated dressings in the treatment of neuropathic diabetic foot ulcers. Int Wound J. 2014;11(3):259-263. https://doi.org/10.1111/j.1742-481X.2012.01082.x

Snyder RJ, Cardinal M, Dauphinée DM, Stavosky J. Reduction in diabetic foot ulcer size. Adv Skin Wound Care. 2010;23(9):406-413. https://doi.org/10.1097/01.ASW.0000383199.64854.9f

Schaper N, van Netten JJ, Apelqvist J. Directrices prácticas sobre la prevención y el tratamiento de la enfermedad del pie diabético (IWGDF 2019). Diabetes Metab Res Rev. 2020;36(S1):e3266. https://doi.org/10.1002/dmrr.3266

Published

2024-06-06

Issue

Section

Original

How to Cite

Alternative treatment of diabetic foot: results of topical honey use in elderly patients. (2024). Integrative Health and Sciences, 1(1), 3. https://doi.org/10.63688/ihs.v1.i1.3